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課程名稱 |
專題研究
Undergraduate Research in Life Science |
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開課學期 |
108-1 |
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授課對象 |
生命科學系 |
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授課教師 |
丁照棣 |
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課號 |
LS3900 |
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課程識別碼 |
B01 49100 |
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班次 |
10 |
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學分 |
1.0 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
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上課地點 |
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備註 |
F群選擇必修。選課前請先徵求授課教師同意。
限學士班二年級以上
總人數上限：10人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
Undergraduate Research is designed for undergraduates who are interested in evolutionary genetic and genomics. Students will focus on a gene annotation project based on materials provided by Genome Education Partnership (GEP, http://gep.wustl.edu). This is part of the Drosophila dot chromosome project, http://gep.wustl.edu/projects/dot_chromosome. Students participate in this project will manually annotate a 40-Kb genome fragment and write a report. After the initial annotation project, students are encourage to work on more genome fragment or work on another project using RNAseq data.
Official Language is English. Students are encourage to communicate in English. International students major in biology are welcome. All students should e-mail the instructor in advance. |
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課程目標 |
The aims of this course is to allow students participating on genome projects through gene annotation project. We will teach students the basic knowledge on genome science. |
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課程要求 |
We expect students finish at least 1 of the following projects:
1. Gene Annotation Project: Annotate one 40-Kb genome fragment
2. RNAseq Project: Gene expression profiling
3. Genotyping by sequencing: SNP profiling |
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預期每週課後學習時數 |
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Office Hours |
備註： Monday 1-4 PM |
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指定閱讀 |
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參考書目 |
[Genomics]
Introduction to Genomics by Arthur M. Lesk (2nd Edition, Oxford University Press, 2011)
A Primer of Genome Science by G. Gibson and S. V. Muse (3rd Edition, Sinauer, 2009)
Genomes 3 by T. A. Brown (Garland Science, 2007) [2nd Ed. available at NCBI,
http://www.ncbi.nlm.nih.gov/books/NBK21128/] |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
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Meet your professor (e-mail her in advance to make an appointment in Week 1) |
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第2週 |
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Review in Genetics |
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第3週 |
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Genome projects |
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第4週 |
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DNA sequencing technologies |
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第5週 |
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Tools in NCBI |
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第6週 |
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Gene expression: cDNA, Northern blotting, microarray, RNAseq |
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第7週 |
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Molecular biology of the gene |
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第8週 |
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Gene Annotation: An introduction |
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第9週 |
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Gene Annotation: A practice project |
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第10週 |
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Gene Annotation: Working projects |
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第11週 |
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Gene Annotation: Working projects |
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第12週 |
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Genetic Variation |
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第13週 |
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Drosophila Population Genomics |
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第14週 |
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Propose a research project based on your annotations |
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第15週 |
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Discussion on research proposal and polite studies if possible |
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